Effect of mushroom diet on pharmacokinetics of gabapentin in healthy Chinese subjects. (July 2014)

• Record Type: Journal Article
• Authors: Toh, Dorothy Su Lin; Limenta, Lie Michael George; Yee, Jie Yin; Wang, Ling‐Zhi; Goh, Boon‐Cher; Murray, Michael; Lee, Edmund Jon Deoon
• Is Part Of: British journal of clinical pharmacology. Volume 78:Number 1(2014:Jul.)
• Page Start: 129
• Page End: 134
• Publication Date: 2014-07
• Subjects: Pharmacology -- Periodicals; Drugs -- Periodicals; 615.1
• DOI: 10.1111/bcp.12273
• Languages: English
• ISSNs: 0306-5251

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="bcp12273-sec-0001" sec-type="section"> <title>Aims</title> <p>This study evaluated the pharmacokinetics of gabapentin in Chinese subjects who received a diet rich in shiitake mushrooms. Shiitake mushrooms have been shown to contain high amount of ergothioneine. <italic>In vitro</italic> studies have shown that OCTN1‐mediated secretion of gabapentin is <italic>trans</italic>‐stimulated by ergothioneine. This study also investigated the concentrations of ergothioneine in plasma at baseline and following mushroom consumption.</p> </sec> <sec id="bcp12273-sec-0002" sec-type="section"> <title>Methods</title> <p>Ten healthy male subjects were recruited and received a diet containing no mushrooms (treatment A) or a high mushroom diet (treatment B; after at least a 7 day washout period) 1 day prior to administration of a single oral dose of gabapentin 600 mg.</p> </sec> <sec id="bcp12273-sec-0003" sec-type="section"> <title>Results</title> <p>Ingestion of shiitake mushrooms produced significant increases in plasma ergothioneine concentrations that were sustained for more than 48 h. A statistically significant but modest increase in the renal clearance (CL<sub>R</sub>) of gabapentin occurred after intake of the mushroom diet (91.1 ± 25.1 <italic>vs</italic>. 76.9 ± 20.6 ml min<sup>−1</sup>, <italic>P</italic> = 0.031). No significant changes in AUC(0, <italic>t</italic><sub>last</sub>) of gabapentin were observed (<italic>P</italic> = 0.726). Creatinine clearance did not correlate with CL<sub>R</sub> of gabapentin at baseline (treatment A). After ingestion of the mushroom diet, creatinine clearance accounted for 65.3% of the variance in CL<sub>R</sub> of gabapentin.</p> </sec> <sec id="bcp12273-sec-0004" sec-type="section"> <title>Conclusions</title> <p>These data suggest that diet–drug pharmacokinetic interactions may occur during co‐exposure to gabapentin and mushroom constituents. However, as it does not affect the AUC(0, <italic>t</italic><sub>last</sub>) of gabapentin, it may not have clinically important consequences. Shiitake mushrooms can also be used as a source of ergothioneine for future clinical studies.</p> </sec> </abstract>