Evaluation of the serum levels of soluble IL‐2 receptor and endothelin‐1 in children with Crimean‐Congo hemorrhagic fever. (10th December 2013)

• Record Type: Journal Article
• Authors: Deveci, Koksal; Oflaz, Mehmet Burhan; Sancakdar, Enver; Uysal, Elif Bilge; Guven, Ahmet Sami; Kaya, Ali; Alkan, Filiz; Cevit, Omer
• Is Part Of: Apmis. Volume 122:Number 7(2014:Jul.)
• Page Start: 643
• Page End: 647
• Publication Date: 2013-12-10
• Subjects: Pathology -- Periodicals; Microbiology -- Periodicals; Immunology -- Periodicals; 572
• DOI: 10.1111/apm.12209
• Languages: English
• ISSNs: 0903-4641

Abstract

<abstract abstract-type="main" id="apm12209-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>We aimed to assess the association between serum levels of soluble IL‐2 receptor (sIL‐2r) and endothelin‐1 and severe infection in children with Crimean‐Congo hemorrhagic fever (CCHF). Fifty‐two patients under 18 years of age with a laboratory‐ confirmed diagnosis of CCHF and 38 healthy controls were enrolled in the study. Patients were classified into two groups based on disease severity (severe group and non‐severe group). The sIL‐2r and endothelin‐1 levels were observed to be significantly higher in patients with severe CCHF compared with those with non‐severe CCHF and the control group (p &lt; 0.05). In addition, those with non‐severe CCHF were also found to have a significantly higher sIL‐2r level relative to the control group (p &lt; 0.001). Although there was a positive correlation between sIL‐2r and endothelin‐1 levels, serum levels of both sIL‐2r and endothelin‐1 were negatively correlated with the platelets count. In children with CCHF, serum levels of sIL‐2r and endothelin‐1 were increased, and this increase is related to the severity of the disease. In this study, we concluded through prognosis that serum levels of sIL‐2r and endothelin‐1 might be related, and that hemophagocytic lymphohistiocytosis and endothelial injury might contribute to a pathogenesis of the disease.</p> </abstract>