ABCA1 rs4149313 Polymorphism and Susceptibility to Coronary Heart Disease: A Meta‐Analysis. (July 2014)

• Record Type: Journal Article
• Authors: Fan, Shu‐Li; Li, Xu; Chen, Si‐Jiao; Qi, Guo‐Xian
• Is Part Of: Annals of human genetics. Volume 78:Number 4(2014:Jul.)
• Page Start: 264
• Page End: 276
• Publication Date: 2014-07
• Subjects: Human genetics -- Periodicals; 599.935
• DOI: 10.1111/ahg.12068
• Languages: English
• ISSNs: 0003-4800

Abstract

<abstract abstract-type="main"> <title>Summary</title> <p>Many existing studies have demonstrated that common polymorphisms in the <italic>ABCA1</italic> gene may play important roles in the development and progression of coronary heart disease (CHD), but individually published results are inconclusive. This meta‐analysis aimed to derive a more precise estimation of the relationship between the <italic>ABCA1</italic> rs4149313 polymorphism and CHD risk. We searched the CISCOM, CINAHL, Web of Science, PubMed, Google Scholar, EBSCO, Cochrane Library, and CBM databases from inception through 1 September 2013. Meta‐analysis was performed using the STATA 12.0 software. Odds ratios (OR) and their 95% confidence intervals (CI) were estimated. Eleven case‐control studies were included with a total of 5416 CHD patients and 20, 897 healthy controls. Our meta‐analysis results revealed that the <italic>ABCA1</italic> rs4149313 polymorphism may be associated with an increased risk of CHD. Subgroup analysis by ethnicity suggested that there were significant associations between the <italic>ABCA1</italic> rs4149313 polymorphism and an increased risk of CHD in Asian populations, but not in Caucasian populations (all <italic>P</italic> > 0.05). Meta‐regression analyses showed that ethnicity may be a main source of heterogeneity. The present meta‐analysis suggests that the <italic>ABCA1</italic> rs4149313 polymorphism may contribute to the risk of CHD, especially in Asian populations.</p> </abstract>