Whole Blood Cells Loaded with Messenger RNA as an Anti‐Tumor Vaccine. Issue 6 (16th December 2013)

• Record Type: Journal Article
• Authors: Phua, Kyle K. L.; Boczkowski, David; Dannull, Jens; Pruitt, Scott; Leong, Kam W.; Nair, Smita K.
• Is Part Of: Advanced healthcare materials. Volume 3:Issue 6(2014:Jun.)
• Page Start: 837
• Page End: 842
• Publication Date: 2013-12-16
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201300512
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adhm201300512-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The use of a cell‐based vaccine</bold> composed of autologous whole blood cells loaded with mRNA is described. Mice immunized with whole blood cells loaded with mRNA encoding antigen develop anti‐tumor immunity comparable to DC‐RNA immunization. This approach offers a simple and affordable alternative to RNA‐based cellular therapy by circumventing complex, laborious and expensive ex vivo manipulations required for DC‐based immunizations. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pghmfn0d1m" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>