High Aspect Ratio Elongated Microparticles for Enhanced Topical Drug Delivery in Human Volunteers. Issue 6 (13th January 2014)

• Record Type: Journal Article
• Authors: Raphael, Anthony P.; Primiero, Clare A.; Lin, Lynlee L.; Smith, Ross Flewell; Dyer, Philip; Soyer, H. Peter; Prow, Tarl W.
• Is Part Of: Advanced healthcare materials. Volume 3:Issue 6(2014:Jun.)
• Page Start: 860
• Page End: 866
• Publication Date: 2014-01-13
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201300517
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adhm201300517-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Delivery of therapeutics into skin is hindered by the epidermal barriers</bold>. To overcome these barriers for the treatment of skin diseases, a cutaneous delivery method capable of field treatment using silica‐elongated microparticles is developed. The microparticles are massaged into the skin using a 3D‐printed microtextured applicator resulting in significant field‐directed drug delivery enhancement. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pghmfn09bt" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>