Developmental genetics of the Caenorhabditis elegans pharynx. (23rd May 2014)
- Record Type:
- Journal Article
- Title:
- Developmental genetics of the Caenorhabditis elegans pharynx. (23rd May 2014)
- Main Title:
- Developmental genetics of the Caenorhabditis elegans pharynx
- Authors:
- Pilon, Marc
- Abstract:
- <abstract abstract-type="main" id="wdev139-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p id="wdev139-para-0001">The <italic>Caenorhabditis elegans</italic> pharynx is a rhythmically pumping organ composed initially of 80 cells that, through fusions, amount to 62 cells in the adult worm. During the first 100 min of development, most future pharyngeal cells are born and gather into a double‐plate primordium surrounded by a basal lamina. All pharyngeal cells express the transcription factor PHA‐4, of which the concentration increases throughout development, triggering a sequential activation of genes with promoters responding differentially to PHA‐4 protein levels. The oblong‐shaped pharyngeal primordium becomes polarized, many cells taking on wedge shapes with their narrow ends toward the center, hence forming an epithelial cyst. The primordium then elongates, and reorientations of the cells at the anterior and posterior ends form the mouth and pharyngeal‐intestinal openings, respectively. The 20 pharyngeal neurons establish complex but reproducible trajectories using 'fishing line' and growth cone‐driven mechanisms, and the gland cells also similarly develop their processes. The genetics behind many fate decisions and morphogenetic processes are being elucidated, and reveal the pharynx to be a fruitful model for developmental biologists. <italic>WIREs Dev Biol</italic> 2014, 3:263–280. doi: 10.1002/wdev.139</p> <p>For further resources related to this<abstract abstract-type="main" id="wdev139-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p id="wdev139-para-0001">The <italic>Caenorhabditis elegans</italic> pharynx is a rhythmically pumping organ composed initially of 80 cells that, through fusions, amount to 62 cells in the adult worm. During the first 100 min of development, most future pharyngeal cells are born and gather into a double‐plate primordium surrounded by a basal lamina. All pharyngeal cells express the transcription factor PHA‐4, of which the concentration increases throughout development, triggering a sequential activation of genes with promoters responding differentially to PHA‐4 protein levels. The oblong‐shaped pharyngeal primordium becomes polarized, many cells taking on wedge shapes with their narrow ends toward the center, hence forming an epithelial cyst. The primordium then elongates, and reorientations of the cells at the anterior and posterior ends form the mouth and pharyngeal‐intestinal openings, respectively. The 20 pharyngeal neurons establish complex but reproducible trajectories using 'fishing line' and growth cone‐driven mechanisms, and the gland cells also similarly develop their processes. The genetics behind many fate decisions and morphogenetic processes are being elucidated, and reveal the pharynx to be a fruitful model for developmental biologists. <italic>WIREs Dev Biol</italic> 2014, 3:263–280. doi: 10.1002/wdev.139</p> <p>For further resources related to this article, please visit the <ext-link ext-link-type="uri" xlink:href="http://wires.wiley.com/remdoi.cgi?doi=10.1002/wdev.139" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">WIREs website</ext-link>.</p> <p id="wdev139-para-0002">Conflict of interest: The author has declared no conflicts of interest for this article.</p> </abstract> … (more)
- Is Part Of:
- Wiley interdisciplinary reviews. Volume 3:Number 4(2014:Jul./Aug.)
- Journal:
- Wiley interdisciplinary reviews
- Issue:
- Volume 3:Number 4(2014:Jul./Aug.)
- Issue Display:
- Volume 3, Issue 4 (2014)
- Year:
- 2014
- Volume:
- 3
- Issue:
- 4
- Issue Sort Value:
- 2014-0003-0004-0000
- Page Start:
- 263
- Page End:
- 280
- Publication Date:
- 2014-05-23
- Subjects:
- Developmental biology -- Periodicals
571.805 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291759-7692 ↗
- DOI:
- 10.1002/wdev.139 ↗
- Languages:
- English
- ISSNs:
- 1759-7684
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 9838.207200
British Library STI - ELD Digital store - Ingest File:
- 3412.xml