Effect of pulsed electromagnetic field therapy on prostate volume and vascularity in the treatment of benign prostatic hyperplasia: A pilot study in a canine model. Issue 11 (9th June 2014)

• Record Type: Journal Article
• Authors: Leoci, Raffaella; Aiudi, Giulio; Silvestre, Fabio; Lissner, Elaine; Lacalandra, Giovanni Michele
• Is Part Of: Prostate. Volume 74:Issue 11(2014)
• Page Start: 1132
• Page End: 1141
• Publication Date: 2014-06-09
• Subjects: Prostate -- Diseases -- Periodicals; 616
• DOI: 10.1002/pros.22829
• Languages: English
• ISSNs: 0270-4137

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="pros22829-sec-0001" sec-type="section"> <title>BACKGROUND</title> <p>Benign prostatic hyperplasia (BPH) is a result of urogenital aging. Recent studies suggest that an age‐related impairment of the blood supply to the lower urinary tract plays a role in the development of BPH and thus may be a contributing factor in the pathogenesis of BPH. The canine prostate is a model for understanding abnormal growth of the human prostate gland. We studied the efficacy of pulsed electromagnetic field therapy (PEMF) in dogs to modify prostate blood flow and evaluated its effect on BPH.</p> </sec> <sec id="pros22829-sec-0002" sec-type="section"> <title>METHODS</title> <p>PEMF (5 min, twice a day for 3 weeks) was performed on 20 dogs affected by BPH. Prostatic volume, Doppler assessment by ultrasonography, libido, semen quality, testosterone levels, and seminal plasma volume, composition and pH were evaluated before and after treatment.</p> </sec> <sec id="pros22829-sec-0003" sec-type="section"> <title>RESULTS</title> <p>The 3 weeks of PEMF produced a significant reduction in prostatic volume (average 57%) without any interference with semen quality, testosterone levels or libido. Doppler parameters showed a reduction of peripheral resistances and a progressive reduction throughout the trial of the systolic peak velocity, end‐diastolic velocity, mean velocity, mean, and peak gradient of the blood flow in the dorsal branch of the prostatic artery. The pulsatility index and the resistance index did not vary significantly over time.</p> </sec> <sec id="pros22829-sec-0004" sec-type="section"> <title>CONCLUSIONS</title> <p>The efficacy of PEMF on BPH in dogs, with no side effects, suggests the suitability of this treatment in humans and supports the hypothesis that impairment of blood supply to the lower urinary tract may be a causative factor in the development of BPH. <italic>Prostate</italic> 74:1132–1141, 2014. © 2014 The Authors. <italic>The Prostate</italic> published by Wiley Periodicals, Inc.</p> </sec> </abstract>