GradientOptimizer: An open‐source graphical environment for calculating optimized gradients in reversed‐phase liquid chromatography. Issue 12 (15th May 2014)

• Record Type: Journal Article
• Authors: Moruz, Luminita; Käll, Lukas
• Is Part Of: Proteomics. Volume 14:Issue 12(2014:Jun.)
• Page Start: 1464
• Page End: 1466
• Publication Date: 2014-05-15
• Subjects: Proteins -- Separation -- Periodicals; Bioinformatics -- Periodicals; Proteomics -- Periodicals; Genomes -- Periodicals; Molecular genetics -- Periodicals; 572.605
• DOI: 10.1002/pmic.201400036
• Languages: English
• ISSNs: 1615-9853

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>We here present GradientOptimizer, an intuitive, lightweight graphical user interface to design nonlinear gradients for separation of peptides by reversed‐phase liquid chromatography. The software allows to calculate three types of nonlinear gradients, each of them optimizing a certain retention time distribution of interest. GradientOptimizer is straightforward to use, requires minimum processing of the input files, and is supported under Windows, Linux, and OS X platforms. The software is open‐source and can be downloaded under an Apache 2.0 license at <ext-link ext-link-type="uri" xlink:href="https://github.com/statisticalbiotechnology/NonlinearGradientsUI" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">https://github.com/statisticalbiotechnology/NonlinearGradientsUI</ext-link>.</p> </abstract>