Effects of balanced deep‐sea water on adipocyte hypertrophy and liver steatosis in high‐fat, diet‐induced obese mice. (25th March 2014)

• Record Type: Journal Article
• Authors: Ha, Byung Geun; Park, Jung‐Eun; Shin, Eun Ji; Shon, Yun Hee
• Is Part Of: Obesity. Volume 22:Number 7(2014:Jul.)
• Page Start: 1669
• Page End: 1678
• Publication Date: 2014-03-25
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20740
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20740-sec-0001" sec-type="section"> <title>Objective</title> <p>To determine the effects of balanced deep‐sea water (BDSW) on adipocyte hypertrophy and liver steatosis in high‐fat diet (HFD)‐induced obese C57BL/6J mice.</p> </sec> <sec id="oby20740-sec-0002" sec-type="section"> <title>Methods</title> <p>BDSW was prepared by mixing deep‐sea water (DSW) mineral extracts and desalinated water. C57BL/6J mice were fed a normal diet or HFD with or without BDSW with different hardness (500, 1000, or 2000) for 20 weeks.</p> </sec> <sec id="oby20740-sec-0003" sec-type="section"> <title>Results</title> <p>BDSW suppressed body weight gain in HFD‐fed mice. Histopathologic assays of the fat and liver revealed that BDSW inhibited the increase in adipocyte size and improved severe liver steatosis in HFD‐fed mice. BDSW suppressed the expression of adipogenic, lipogenic, lipolytic, and pro‐inflammatory cytokine genes and increased the expression of adipokines and β‐oxidation genes in fat. In the liver, BDSW suppressed the expression of genes involved in lipogenesis and cholesterol synthesis, and increased the expression of genes related to β‐oxidation. Furthermore, BDSW improved the impaired phosphorylation of IRS‐1, LKB1, AMPK, and mTOR in fat and liver tissues of HFD‐fed mice.</p> </sec> <sec id="oby20740-sec-0004" sec-type="section"> <title>Conclusions</title> <p>These results suggest that BDSW has potential as an anti‐lipidemic agent, given its ability to suppress body weight gain and liver steatosis through the regulation of lipid metabolism by signal molecule activation.</p> </sec> </abstract>