Glucocorticoids in laryngology: A review. (28th January 2014)

• Record Type: Journal Article
• Authors: Rafii, Benjamin; Sridharan, Shaum; Taliercio, Salvatore; Govil, Nandini; Paul, Benjamin; Garabedian, Michael J.; Amin, Milan R.; Branski, Ryan C.
• Is Part Of: Laryngoscope. Volume 124:Number 7(2014:Jul.)
• Page Start: 1668
• Page End: 1673
• Publication Date: 2014-01-28
• Subjects: Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.24556
• Languages: English
• ISSNs: 0023-852X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="lary24556-sec-0001" sec-type="section"> <title>Objectives/Hypothesis</title> <p>To provide the otolaryngologist an evidence‐based sound review of glucocorticoid use for laryngeal pathology.</p> </sec> <sec id="lary24556-sec-0002" sec-type="section"> <title>Study Design</title> <p>Review of contemporary peer‐reviewed literature as well as review articles.</p> </sec> <sec id="lary24556-sec-0003" sec-type="section"> <title>Methods</title> <p>A review of the literature regarding glucocorticoids as a therapeutic intervention for the treatment of benign laryngeal pathology and laryngeal manifestations of systemic disease was performed. Review included both systemic administration as well as local injection.</p> </sec> <sec id="lary24556-sec-0004" sec-type="section"> <title>Results</title> <p>Glucocorticoids, administered in the critical care setting for planned extubation, markedly reducing the risk of reintubation and remain a rudimentary pharmacologic adjunct in laryngeal manifestations of common autoimmune and inflammatory disorders. Intralesional injection has reduced the rate of surgical intervention for benign inflammatory primary laryngeal pathology.</p> </sec> <sec id="lary24556-sec-0005" sec-type="section"> <title>Conclusions</title> <p>Glucocorticoids are effective in the treatment of a number of laryngeal pathologies, through both systemic and intralesional administration. However, a clear consensus for utilization of glucocorticoids in the treatment of specific laryngeal disorders has yet to be published.</p> </sec> <sec id="lary24556-sec-0006" sec-type="section"> <title>Level of Evidence</title> <p> <italic>Laryngoscope</italic>, 124:1668–1673, 2014</p> </sec> </abstract>