Sucrose/Glucose Molecular Alloys by Cryomilling. Issue 7 (27th May 2014)

• Record Type: Journal Article
• Authors: Megarry, Andrew J.; Booth, Jonathan; Burley, Jonathan
• Is Part Of: Journal of pharmaceutical sciences. Volume 103:Issue 7(2014:Jul.)
• Page Start: 2098
• Page End: 2106
• Publication Date: 2014-05-27
• Subjects: Pharmacy -- Periodicals; 615.1
• DOI: 10.1002/jps.24027
• Languages: English
• ISSNs: 0022-3549

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>We report here for the first time a series of amorphous sucrose/glucose molecular alloys prepared by cryomilling. Differential scanning calorimetry, X‐ray powder diffraction and solution proton nuclear magnetic resonance showed that cryomilling drives a direct transformation from a two‐phase mixture of crystalline sucrose and glucose, to a single‐phase amorphous sucrose/glucose molecular alloy. The molecular alloys displayed a single <italic>T</italic>_g which varied linearly with composition. The effect of atmospheric moisture and the possibility of localised melting of the material because of milling‐related friction were also discussed. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:2098–2106, 2014</p> </abstract>