Decreased aorto‐septal angle may contribute to left ventricular diastolic dysfunction in healthy subjects. Issue 6 (17th January 2014)

• Record Type: Journal Article
• Authors: Okada, Kazunori; Mikami, Taisei; Kaga, Sanae; Nakabachi, Masahiro; Abe, Ayumu; Yokoyama, Shinobu; Nishino, Hisao; Nishida, Mutsumi; Shimizu, Chikara; Iwano, Hiroyuki; Yamada, Satoshi; Tsutsui, Hiroyuki
• Is Part Of: Journal of clinical ultrasound. Volume 42:Issue 6(2014:Jul./Aug.)
• Page Start: 341
• Page End: 347
• Publication Date: 2014-01-17
• Subjects: Ultrasonics in medicine -- Periodicals; 616.07543
• DOI: 10.1002/jcu.22126
• Languages: English
• ISSNs: 0091-2751

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="jcu22126-sec-0001" sec-type="section"> <title>Background</title> <p>Left ventricular (LV) diastolic dysfunction is often observed in healthy older subjects without structural heart disease, although its exact mechanisms have not been established. A decrease in the aorto‐septal angle (ASA), an alteration of LV shape due to aortic elongation, is also frequently seen in elderly subjects. The objective of this study was to evaluate whether it can contribute to LV diastolic dysfunction in healthy subjects.</p> </sec> <sec id="jcu22126-sec-0002" sec-type="section"> <title>Methods</title> <p>Echocardiography was performed in 77 healthy subjects (42 men, mean age 43.2 ± 13.8 years) to measure the ASA, early diastolic transmitral flow velocity (E), isovolumic relaxation time (IRT), and early diastolic mitral annular velocity (e′). The LV peak early diastolic longitudinal strain rate (GSR<sub>E</sub>) was measured using a two‐dimensional speckle tracking imaging technique.</p> </sec> <sec id="jcu22126-sec-0003" sec-type="section"> <title>Results</title> <p>ASA was significantly correlated with E (<italic>r</italic> = 0.54, <italic>p</italic> < 0.001), IRT (<italic>r</italic> = −0.41, <italic>p</italic> < 0.001), e′ (<italic>r</italic> = 0.57, <italic>p</italic> < 0.001), and GSR<sub>E</sub> (<italic>r</italic> = 0.63, <italic>p</italic> < 0.001) and shown by stepwise multivariate analysis to be the strongest independent determinant of E, IRT, and GSR<sub>E</sub>, and one of the independent determinants of e′.</p> </sec> <sec id="jcu22126-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The alteration of LV shape associated with reduced ASA may be one of the causes of LV diastolic dysfunction independently of age in otherwise healthy subjects. © 2014 Wiley Periodicals, Inc. <italic>J Clin Ultrasound</italic><bold>42</bold>:341–347, 2014</p> </sec> </abstract>