A Stereoselective Total Synthesis of Decarestrictine I. Issue 6 (June 2014)

• Record Type: Journal Article
• Authors: Yadav, Jhillu Singh; Venkatesh, Miriyal; Kumar, Alleni Suman; Reddy, Poli Adi Narayana; Reddy, Basi V. Subba; Prasad, Attaluri R.
• Is Part Of: Helvetica chimica acta. Volume 97:Issue 6(2014:Jun.)
• Page Start: 830
• Page End: 838
• Publication Date: 2014-06
• Subjects: Chemistry -- Periodicals; Chemistry, Analytical -- periodicals; Chimie -- Périodiques; 540
• DOI: 10.1002/hlca.201300256
• Languages: English
• ISSNs: 0018-019X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A convergent and stereoselective total synthesis of decarestrictine I, a polyketide natural product, is described. Both acid and alcohol fragments were prepared from the readily available <sc>L</sc>‐malic acid <italic>via StillGennari</italic> olefination and <italic>Sharpless</italic> asymmetric epoxidation. The <italic>Steglich</italic> esterification and ring‐closing metathesis (RCM) are employed to combine both acid and alcohol fragments.</p> </abstract>