High prevalence of immunoglobulin light chain gene aberrations as revealed by FISH in multiple myeloma and MGUS. Issue 8 (12th April 2014)

• Record Type: Journal Article
• Authors: Türkmen, Seval; Binder, Anastasia; Gerlach, Antje; Niehage, Sylke; Theodora Melissari, Maria; Inandiklioglu, Nihal; Dörken, Bernd; Burmeister, Thomas
• Is Part Of: Genes, chromosomes & cancer. Volume 53:Issue 8(2014:Aug.)
• Page Start: 650
• Page End: 656
• Publication Date: 2014-04-12
• Subjects: Cancer -- Genetic aspects -- Periodicals; 616.994042
• DOI: 10.1002/gcc.22175
• Languages: English
• ISSNs: 1045-2257

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Multiple myeloma (MM) is a malignant B‐cell neoplasm characterized by an uncontrolled proliferation of aberrant plasma cells in the bone marrow. Chromosome aberrations in MM are complex and represent a hallmark of the disease, involving many chromosomes that are altered both numerically and structurally. Nearly half of the cases are nonhyperdiploid and show <italic>IGH</italic> translocations with the following partner genes: <italic>CCND1</italic>, <italic>FGFR3</italic> and <italic>MMSET</italic>, <italic>MAF</italic>, <italic>MAFB</italic>, and <italic>CCND3</italic>. The remaining 50% are grouped into a hyperdiploid group that is characterized by multiple trisomies involving chromosomes 3, 5, 7, 9, 11, 15, 19, and 21. In this study, we analyzed the immunoglobulin light chain kappa (<italic>IGK</italic>, 2p12) and lambda (<italic>IGL</italic>, 22q11) loci in 150 cases, mostly with MM but in a few cases monoclonal gammopathy of undetermined significance (MGUS), without <italic>IGH</italic> translocations. We identified aberrations in 27% (= 40 patients) including rearrangements (12%), gains (12%), and deletions (4.6%). In 6 of 18 patients with <italic>IGK</italic> or/and <italic>IGL</italic> rearrangements, we detected a <italic>MYC</italic> rearrangement which suggests that <italic>MYC</italic> is the translocation partner in the majority of these cases. © 2014 Wiley Periodicals, Inc.</p> </abstract>