MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division. (5th March 2014)

• Record Type: Journal Article
• Authors: Zinin, Nikolay; Adameyko, Igor; Wilhelm, Margareta; Fritz, Nicolas; Uhlén, Per; Ernfors, Patrik; Henriksson, Marie Arsenian
• Is Part Of: EMBO reports. Volume 15:Number 4(2014:Apr.)
• Page Start: 383
• Page End: 391
• Publication Date: 2014-03-05
• Subjects: Molecular biology -- Periodicals; Molecular Biology -- Periodicals; Molecular biology; Periodicals; 572.8
• DOI: 10.1002/embr.201337424
• Languages: English
• ISSNs: 1469-221X

Abstract

<abstract abstract-type="synopsis" xml:lang="en" id="embr201337424-abs-0002"> <title>Synopsis</title> <p> <boxed-text content-type="graphic" id="embr201337424-blkfxd-0001" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pghjsq58bh" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> <p>This study reveals an unexpected role for MYC in the control of stemness versus differentiation of neural stem cells <italic>in vivo</italic> and shows that Myc represses Notch signaling and promotes asymmetric neurogenic cell divisions.</p> <p> <list id="embr201337424-list-0001" list-type="bullet"> <list-item> <p>Elevated MYC levels increase neurogenesis in the developing chick neural tube</p> </list-item> <list-item> <p>The neurogenic function of MYC depends on the integrity of the polarized neural tissue</p> </list-item> <list-item> <p>MYC promotes apico‐basal neurogenic divisions</p> </list-item> </list> </p> </abstract>