The expression level of small non‐coding RNAs derived from the first exon of protein‐coding genes is predictive of cancer status. (17th February 2014)

• Record Type: Journal Article
• Authors: Zovoilis, Athanasios; Mungall, Andrew J; Moore, Richard; Varhol, Richard; Chu, Andy; Wong, Tina; Marra, Marco; Jones, Steven JM
• Is Part Of: EMBO reports. Volume 15:Number 4(2014:Apr.)
• Page Start: 402
• Page End: 410
• Publication Date: 2014-02-17
• Subjects: Molecular biology -- Periodicals; Molecular Biology -- Periodicals; Molecular biology; Periodicals; 572.8
• DOI: 10.1002/embr.201337950
• Languages: English
• ISSNs: 1469-221X

Abstract

<abstract abstract-type="synopsis" xml:lang="en" id="embr201337950-abs-0002"> <title>Synopsis</title> <p> <boxed-text content-type="graphic" id="embr201337950-blkfxd-0001" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pghjsq56n6" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> <p>The expression of small non‐coding RNAs encoded within the first exon of genes can be used to efficiently identify cancer samples and classify patients into subgroups of different survival. Such pan‐cancer association is the first link between these RNAs and disease.</p> <p> <list id="embr201337950-list-0001" list-type="bullet"> <list-item> <p>Exon 1 small non‐coding RNAs (smRNAs) can distinguish between cancer and normal tissues.</p> </list-item> <list-item> <p>The prediction potential of exon 1 smRNAs differs from that of other smRNAs around transcriptional start sites (TSS).</p> </list-item> <list-item> <p>smRNA locations around TSS are conserved between different individuals.</p> </list-item> <list-item> <p>smRNA locations are enriched within CpG islands and their levels negatively correlated with DNA methylation.</p> </list-item> </list> </p> </abstract>