Specific calcineurin targeting in macrophages confers resistance to inflammation via MKP‐1 and p38. (4th March 2014)

• Record Type: Journal Article
• Authors: Escolano, Amelia; Martínez‐Martínez, Sara; Alfranca, Arántzazu; Urso, Katia; Izquierdo, Helena M; Delgado, Mario; Martín, Francisco; Sabio, Guadalupe; Sancho, David; Gómez‐del Arco, Pablo; Redondo, Juan Miguel
• Is Part Of: EMBO journal. Volume 33:Number 10(2014)
• Page Start: 1117
• Page End: 1133
• Publication Date: 2014-03-04
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.1002/embj.201386369
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="synopsis" xml:lang="en" id="embj201386369-abs-0002"> <title>Synopsis</title> <p> <boxed-text content-type="graphic" id="embj201386369-blkfxd-0011" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pghjspkdcx" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> <p>Targeting of calcineurin in macrophages unveils their anti‐inflammatory activity, which bears significant potential for therapeutic exploitation.</p> <p> <list id="embj201386369-list-0001" list-type="bullet"> <list-item> <p>Calcineurin deletion or inhibition with LxVP peptide, but not the immunosuppressive drugs CsA or FK506, induces anti‐inflammatory macrophages.</p> </list-item> <list-item> <p>p38 activity mediates the anti‐inflammatory activation induced by specific calcineurin targeting in macrophages.</p> </list-item> <list-item> <p>Calcineurin targeting releases p38 from MKP‐1‐mediated repression.</p> </list-item> <list-item> <p>In gene or cell therapy approaches, specific calcineurin targeting in macrophages confers resistance to inflammation associated with arthritis and contact hypersensitivity.</p> </list-item> </list> </p> </abstract>