Asymmetric neural development in the Caenorhabditis elegans olfactory system. Issue 6 (7th February 2014)

• Record Type: Journal Article
• Authors: Hsieh, Yi‐Wen; Alqadah, Amel; Chuang, Chiou‐Fen; Halpern, Marnie E.; Hobert, Oliver; Wright, Christopher V. E.
• Is Part Of: Genesis. Volume 52:Issue 6(2014:Jun.)
• Page Start: 544
• Page End: 554
• Publication Date: 2014-02-07
• Subjects: Developmental genetics -- Periodicals; Genetics -- Periodicals; Developmental biology -- Periodicals; Embryology -- Periodicals; Genetic regulation -- Periodicals; 576.5
• DOI: 10.1002/dvg.22744
• Languages: English
• ISSNs: 1526-954X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>SUMMARY: Asymmetries in the nervous system have been observed throughout the animal kingdom. Deviations of brain asymmetries are associated with a variety of neurodevelopmental disorders; however, there has been limited progress in determining how normal asymmetry is established in vertebrates. In the <italic>Caenorhabditis elegans</italic> chemosensory system, two pairs of morphologically symmetrical neurons exhibit molecular and functional asymmetries. This review focuses on the development of antisymmetry of the pair of <underline>a</underline>mphid <underline>w</underline>ing "<underline>C</underline>" (AWC) olfactory neurons, from transcriptional regulation of general cell identity, establishment of asymmetry through neural network formation and calcium signaling, to the maintenance of asymmetry throughout the life of the animal. Many of the factors that are involved in AWC development have homologs in vertebrates, which may potentially function in the development of vertebrate brain asymmetry. genesis 52:544–554, 2014. © 2014 Wiley Periodicals, Inc.</p> </abstract>