Access to 1, 2‐Dihydroisoquinolines through Gold‐Catalyzed Formal [4+2] Cycloaddition. Issue 26 (23rd May 2014)

• Record Type: Journal Article
• Authors: Xin, Zhuo; Kramer, Søren; Overgaard, Jacob; Skrydstrup, Troels
• Is Part Of: Chemistry. Volume 20:Issue 26(2014)
• Page Start: 7926
• Page End: 7930
• Publication Date: 2014-05-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201403290
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A new synthetic route to the privileged 1, 2‐dihydroisoquinolines is reported. This method, which relies on a gold‐catalyzed formal [4+2] cycloaddition between ynamides and imines, provides a new retrosynthetic disconnection of the 1, 2‐dihydroisoquinoline core by installing the 1, 8a CC and 2, 3 CN bonds in one step. Both aldimines and ketimines can be used as substrates. In addition, one example of dihydrofuropyridine synthesis is also demonstrated.</p> </abstract>