Cytotoxic Compounds from the Leaves of Garcinia polyantha. Issue 6 (June 2014)

• Record Type: Journal Article
• Authors: Lannang, Alain Meli; Tatsimo, Simplice J. N.; Fouotsa, Hugues; Dzoyem, Jean Paul; Saxena, Ajit Kumar; Sewald, Norbert
• Is Part Of: Chemistry & biodiversity. Volume 11:Issue 6(2014:Jun.)
• Page Start: 975
• Page End: 981
• Publication Date: 2014-06
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201300401
• Languages: English
• ISSNs: 1612-1872

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A new compound, named banganxanthone C (=12‐(1, 1‐dimethylprop‐2‐en‐1‐yl)‐5, 10‐dihydroxy‐9‐methoxy‐2‐methyl‐2‐(4‐methylpent‐3‐en‐1‐yl)‐2<italic>H</italic>, 6<italic>H</italic>‐pyrano[3, 2‐<italic>b</italic>]xanthen‐6‐one; <bold>4</bold>), together with five known compounds, were isolated from the leaves of <italic>Garcinia polyantha.</italic> The structures of the compounds were elucidated on the basis of 1D‐ and 2D‐NMR spectroscopy. Among the known compounds, two were xanthones, one was a pentacyclic triterpene, one sterol, and one benzophenone derivative. Isoxanthochymol (<bold>2</bold>) and 4‐[(2<italic>E</italic>)‐3, 7‐dimethylocta‐2, 6‐dien‐1‐yl]‐1, 5, 8‐trihydroxy‐3‐methoxy‐9<italic>H</italic>‐xanthen‐9‐one (<bold>3</bold>) exhibited significant antiproliferative activity against the leukemia cell line TPH‐1 with <italic>IC</italic>₅₀ inhibition values of 1.5 and 2.8 μg/ml, respectively. The cytotoxic activity was found to be related to apoptosis induction.</p> </abstract>