Lack of genetic susceptibility of KCNJ11 E23K polymorphism with risk of type 2 diabetes in an Iranian population. (August 2014)

• Record Type: Journal Article
• Authors: Keshavarz, Parvaneh; Habibipour, Razie; Ghasemi, Malaeke; Kazemnezhad, Ehsan; Alizadeh, Maryam; Omami, Mohammad Hasan Hedayati
• Is Part Of: Endocrine research. Volume 39:Number 3(2014:Aug.)
• Page Start: 120
• Page End: 125
• Publication Date: 2014-08
• Subjects: Endocrinology, Experimental -- Periodicals; Endocrinology -- Periodicals; Endocrinology -- Periodicals; Research -- Periodicals; 616.4
• DOI: 10.3109/07435800.2013.860607
• Languages: English
• ISSNs: 0743-5800

Abstract

<abstract> <title>Abstract</title> <p> <italic>Aims</italic>: The <italic>KCNJ11</italic> gene has a strong effect on glucose-stimulated insulin secretion. Common polymorphism KCNJ11 E23K has been reported to be associated with type 2 diabetes in various European-descent populations. However, there were inconsistent results in previous studies in Asian populations, and no study has been carried out in the Iranian population. We examined the contribution of <italic>KCNJ11 E23K</italic> variant in the susceptibility to type 2 diabetes in the Iranian population. <italic>Methods</italic>: We undertook a population-based association study between type 2 diabetes and <italic>E23K</italic> mutation using 400 people with type 2 diabetes and 420 controls. Genotyping was performed using TaqMan technology on an ABI7300 system. <italic>Results</italic>: No significant difference was observed in either genotype distribution (<italic>p</italic> = 0.71) or allele frequency (<italic>p</italic> = 0.88) between individuals with and without type 2 diabetes. After adjusting for the confounding effects of age, gender and body mass index (BMI), no significant effect of genotypes on type 2 diabetes was found regarding any genetic models tested (recessive, dominant or co-dominant models). Following subgroup analysis of individuals with and without diabetes based on BMI, a nominal significant association was observed between type 2 diabetes in the presence of obesity and E23K genotype in the recessive model (<italic>p</italic> = 0.03). <italic>Conclusion</italic>: The KCNJ11 E23K polymorphism is not associated with genetic susceptibility to type 2 diabetes in the Iranian population; however, it may play a role in disease progression in the presence of obesity.</p> </abstract>