The odontogenic-related microinflammation in patients with chronic kidney disease. (July 2014)

• Record Type: Journal Article
• Authors: Niedzielska, Iwona; Chudek, Jerzy; Kowol, Izabela; Slabiak-Blaz, Natalia; Kolonko, Aureliusz; Kuczera, Piotr; Wiecek, Andrzej
• Is Part Of: Renal failure. Volume 36:Number 6(2014)
• Page Start: 883
• Page End: 888
• Publication Date: 2014-07
• Subjects: Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.3109/0886022X.2014.894764
• Languages: English
• ISSNs: 0886-022X

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objectives</italic>: This study estimated plasma levels of interleukin IL-1β, IL-6, tumour necrosis factor-α (TNF-α), interferon-γ (INF-γ) in chronic kidney disease (CKD) patients with a single odontogenic pathology. <italic>Material and methods</italic>: Forty-nine selected adult CKD patients with single odontogenic pathology based on clinical and X-ray examination: patients after proper root canal treatment, without periapical lesions (<italic>n</italic> = 12), with pulp necrosis (<italic>n</italic> = 7), with asymptomatic periapical lesions (<italic>n</italic> = 22), with periodontal disease (<italic>n</italic> = 8), and 14 with healthy teeth were enrolled. Patients with coexisting different dental pathologies and the evidence of other infection were excluded. In all patients plasma concentrations of CRP, IL-1β, IL-6, TNF-α, and INF-γ were measured. <italic>Results</italic>: Patients with periodontitis were characterized by increased concentrations of IL-6 and TNF-α. Those with pulp necrosis had significantly more frequently serum CRP level over 2 mg/L and presented significantly elevated IL-6, but decreased TNF-α concentration than in the subjects with healthy teeth. In patients with periapical lesions and patients after root canal therapy, the concentrations of cytokines did not indicate for the systemic inflammation. <italic>Conclusions</italic>: Periodontitis and pulp necrosis are important sources of systemic microinflammation in CKD patients. Plasma concentrations of IL-6 and TNF-α appear to be more sensitive markers of odontogenic inflammation in CKD patients than CRP.</p> </abstract>