Catalytic CH Amination: A Reaction Now Accessible to Engineered Natural Enzymes1. Issue 27 (4th June 2014)

• Record Type: Journal Article
• Authors: Mahy, Jean‐Pierre; Ciesielski, Jennifer; Dauban, Philippe
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 27(2014)
• Page Start: 6862
• Page End: 6864
• Publication Date: 2014-06-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201403654
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Catalytic CH aminations</bold> with natural enzymes have not been reported thus far. However, when a cytochrome P450 enzyme is modified by switching from an iron(III) to an iron(II) center and by mutating amino acids that are critical for the catalytic activity of this monooxygenase, this modified enzyme catalyzes the intramolecular CH amination of benzenesulfonyl azides.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pghmpb4qv3" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>