Sirtuin to the rescue: SIRT2 extends life span of BubR1 mice. (11th June 2014)

• Record Type: Journal Article
• Authors: Cosentino, Claudia; Mostoslavsky, Raul
• Is Part Of: EMBO journal. Volume 33:Number 13(2014)
• Page Start: 1417
• Page End: 1419
• Publication Date: 2014-06-11
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201488983
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="main" id="embj201488983-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p content-type="executiveSummary">Why and how we age remains a topic that has kept molecular biologists busy for the past few decades. In recent years, several studies pointed to sirtuins as important players in lifespan regulation, yet, <italic>in vivo</italic> proof for most of the mammalian homologs was missing. In this issue of <italic>The EMBO Journal</italic>, Sinclair and colleagues provide novel evidence that SIRT2 is indeed a critical modulator of aging <italic>in vivo</italic>.</p> </abstract>