MiRNAs at the interface of cellular stress and disease. (27th May 2014)

• Record Type: Journal Article
• Authors: Emde, Anna; Hornstein, Eran
• Is Part Of: EMBO journal. Volume 33:Number 13(2014)
• Page Start: 1428
• Page End: 1437
• Publication Date: 2014-05-27
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201488142
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="main" id="embj201488142-abs-0001"> <title>Abstract</title> <p>microRNAs (miRNAs) are a family of small, non‐coding RNAs, which provides broad silencing activity of mRNA targets in a sequence‐dependent fashion. This review explores the hypothesis that the miRNA machinery is intimately linked with the cellular stress pathway and apparatus. Stress signaling potentially alters the function of the miRNA‐bioprocessing core components and decompensates regulation. In addition, dysregulation of miRNA activity renders the cell more prone to stress and emerges as a new pathway for age‐related insults and diseases, such as neurodegeneration.</p> </abstract>