Evaluation of serum thyroid hormones in dogs with systemic inflammatory response syndrome or sepsis. (3rd April 2014)

• Record Type: Journal Article
• Authors: Pashmakova, Medora B.; Bishop, Micah A.; Steiner, Jörg M.; Suchodolski, Jan S.; Barr, James W.
• Is Part Of: Journal of veterinary emergency and critical care. Volume 24:Number 3(2014:May/Jun.)
• Page Start: 264
• Page End: 271
• Publication Date: 2014-04-03
• Subjects: Veterinary emergencies -- Periodicals; Veterinary critical care -- Periodicals; 636.089
• DOI: 10.1111/vec.12172
• Languages: English
• ISSNs: 1479-3261

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="vec12172-sec-0010" sec-type="section"> <title>Objective</title> <p>To determine whether dogs with systemic inflammatory response syndrome (SIRS) or sepsis have derangements in serum thyroid hormone concentrations and to evaluate whether such derangements relate to illness severity or outcome.</p> </sec> <sec id="vec12172-sec-0020" sec-type="section"> <title>Design</title> <p>Prospective observational study. Dogs hospitalized with SIRS or sepsis between May and December 2010 were included. Serum thyroid hormone concentrations were measured in all dogs. Data obtained on admission were used to calculate the Acute Patient Physiologic and Laboratory Evaluation (APPLE) scores.</p> </sec> <sec id="vec12172-sec-0030" sec-type="section"> <title>Setting</title> <p>University teaching hospital.</p> </sec> <sec id="vec12172-sec-0040" sec-type="section"> <title>Animals</title> <p>Twenty‐two consecutive client‐owned dogs hospitalized with SIRS or sepsis were enrolled; 18 dogs completed the study and 4 dogs were excluded for incomplete data. Forty‐nine healthy dogs owned by volunteers were used as controls.</p> </sec> <sec id="vec12172-sec-0050" sec-type="section"> <title>Interventions</title> <p>None.</p> </sec> <sec id="vec12172-sec-0060" sec-type="section"> <title>Measurements and Main Results</title> <p>Decreased total thyroxine (TT4) concentrations were documented in all septic and 7/9 dogs with SIRS. Free T4 concentrations were decreased, but were within the reference interval in 12/18 dogs with SIRS or sepsis compared to control dogs (<italic>P</italic> < 0.001). Dogs with increased APPLE(fast) scores were less likely to survive (<italic>P</italic> = 0.017).</p> </sec> <sec id="vec12172-sec-0070" sec-type="section"> <title>Conclusions</title> <p>Dogs with SIRS or sepsis have derangements in measured serum thyroid hormones. No relationships were identified between thyroid hormone concentrations and survival. The APPLE(fast) score was the only variable predictive of poor outcome.</p> </sec> </abstract>