Severe pertussis and hyperleukocytosis: is it time to change for exchange?. Issue 6 (16th December 2013)

• Record Type: Journal Article
• Authors: Kuperman, Amir; Hoffmann, Yoav; Glikman, Danny; Dabbah, Husein; Zonis, Zeev
• Is Part Of: Transfusion. Volume 54:Issue 6(2014)
• Page Start: 1630
• Page End: 1633
• Publication Date: 2013-12-16
• Subjects: Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; Blood Group Antigens -- Periodicals; Blood Preservation -- Periodicals; Blood Transfusion -- Periodicals; 615
• DOI: 10.1111/trf.12519
• Languages: English
• ISSNs: 0041-1132

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="trf12519-sec-0001" sec-type="section"> <title>Background</title> <p>Pertussis is an important cause of infant death worldwide and continues to be a public health concern even in countries with high vaccination coverage. Severe (critical) pertussis with hyperleukocytosis is a severe form of the disease with up to 80% mortality rate. Attempts have been reported to reduce the white blood cell burden by exchange transfusion (ET) with conflicting conclusions.</p> </sec> <sec id="trf12519-sec-0002" sec-type="section"> <title>Case Report</title> <p>We report a case of critical pertussis in a neonate who was treated with ET, in view of a comprehensive literature review.</p> </sec> <sec id="trf12519-sec-0003" sec-type="section"> <title>Results</title> <p>The patient was discharged without any sequelae.</p> </sec> <sec id="trf12519-sec-0004" sec-type="section"> <title>Conclusion</title> <p>ET should be considered in all infants suffering from critical pertussis and hyperleukocytosis, even in secondary care community hospitals.</p> </sec> </abstract>