Haemodynamic changes in pulmonary hypertension in patients with interstitial lung disease treated with PDE‐5 inhibitors. Issue 5 (3rd April 2014)

• Record Type: Journal Article
• Authors: Zimmermann, Gregor S.; von Wulffen, Werner; Huppmann, Patrick; Meis, Tobias; Ihle, Franziska; Geiseler, Jens; Leuchte, Hanno H.; Tufman, Amanda; Behr, Juergen; Neurohr, Claus
• Is Part Of: Respirology. Volume 19:Issue 5(2014)
• Page Start: 700
• Page End: 706
• Publication Date: 2014-04-03
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Periodicals; 612.2
• DOI: 10.1111/resp.12294
• Languages: English
• ISSNs: 1323-7799

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="resp12294-sec-0001" sec-type="section"> <title>Background and objective</title> <p>Interstitial lung diseases (ILD) are often associated with pulmonary hypertension (PH). This study aimed to evaluate the therapeutic benefit of phosphodiesterase‐5 (PDE‐5) inhibitors in pulmonary hypertension secondary to ILD.</p> </sec> <sec id="resp12294-sec-0002" sec-type="section"> <title>Methods</title> <p>Patients with ILD and PH were treated with sildenafil or tadalafil. Right heart catheterization was performed before and after a minimum of 3‐month treatment. In addition, lung function, 6‐min walk distance (6MWD) and plasma brain natriuretic peptide (BNP) concentration were assessed.</p> </sec> <sec id="resp12294-sec-0003" sec-type="section"> <title>Results</title> <p>Ten ILD patients (three female, mean age 64.4 ± 9.0 years, six with idiopathic pulmonary fibrosis (IPF), four with hypersensitivity pneumonitis, (HP)) with significant precapillary PH (mean pulmonary artery pressure (PAPm) ≥ 25 mmHg, pulmonary vascular resistance (PVR) > 280 dyn*s*cm<sup>−5</sup>; pulmonary artery wedge pressure (PAWPm) ≤ 15 mmHg) were treated with either sildenafil (<italic>n</italic> = 5) or tadalafil (<italic>n</italic> = 5). Pulmonary haemodynamics were severely impaired at baseline (PAPm 42.9 ± 5.4 mmHg; cardiac index (CI) 2.7 ± 0.6 L/min/m<sup>2</sup>; PVR 519 ± 131 dyn × sec × cm<sup>−5</sup>). After mean follow‐up of 6.9 ± 5.8 months an increase in CI (2.9 ± 0.7 L/min/m<sup>2</sup>, <italic>P</italic> = 0.04) and a decrease in PVR (403 ± 190 dyn × sec × cm<sup>−5</sup>, <italic>P</italic> = 0.03) were observed. 6MWD and BNP did not change significantly.</p> </sec> <sec id="resp12294-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Our data suggest that treatment with PDE‐5 inhibitors improves pulmonary haemodynamic patients with PH secondary to ILD.</p> </sec> </abstract>