Immuno‐Chemotherapeutic Platinum(IV) Prodrugs of Cisplatin as Multimodal Anticancer Agents1. (20th May 2014)

• Record Type: Journal Article
• Authors: Wong, Daniel Yuan Qiang; Yeo, Charmian Hui Fang; Ang, Wee Han
• Is Part Of: Angewandte Chemie. Volume 126:Number 26(2014)
• Page Start: 6870
• Page End: 6874
• Publication Date: 2014-05-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201402879
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>There is growing consensus that the clinical therapeutic efficacy of some chemotherapeutic agents depends on their off‐target immune‐modulating effects. Pt anticancer drugs have previously been identified to be potent immunomodulators of both the innate and the adaptive immune system. Nevertheless, there has been little development in the rational design of Pt‐based chemotherapeutic agents to exploit their immune‐activating capabilities. The FPR1/2 formyl peptide receptors are highly expressed in immune cells, as well as in many metastatic cancers. Herein, we report a rationally designed multimodal Pt^IV prodrug containing a FPR1/2‐targeting peptide that combines chemotherapy with immunotherapy to achieve therapeutic synergy and demonstrate the feasibility of this approach.</p> </abstract>