Influence of allograft weight to recipient bodyweight ratio on outcome of cadaveric renal transplantation. Issue 7 (16th June 2014)

• Record Type: Journal Article
• Authors: Codas, Ricardo; Danjou, Fabrice; Dagot, Celine; Martin, Xavier; Morelon, Emmanuel; Badet, Lionel; Hanf, William; Petruzzo, Palmina
• Is Part Of: Nephrology. Volume 19:Issue 7(2014)
• Page Start: 420
• Page End: 425
• Publication Date: 2014-06-16
• Subjects: Nephrology -- Periodicals; Kidneys -- Diseases -- Periodicals; Nephrologists -- Periodicals; 616.61; 616.61
• DOI: 10.1111/nep.12277
• Languages: English
• ISSNs: 1320-5358

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="nep12277-sec-0001" sec-type="section"> <title>Aim</title> <p>One of the factors that may affect survival and function of kidney graft is its functional mass.</p> </sec> <sec id="nep12277-sec-0002" sec-type="section"> <title>Methods</title> <p>In a prospective study, we investigated the impact of the ratio between donor kidney weight in grams and recipient bodyweight in kilograms (DKW/RBW) on creatinine clearance, inulin clearance, and proteinuria: 154 kidneys from deceased donors were weighed and the mean kidney weight was 227 ± 59 g, the bodyweight of the recipients was 64 ± 19 kg.</p> </sec> <sec id="nep12277-sec-0003" sec-type="section"> <title>Results</title> <p>This study showed significant lower values of modification of diet in renal disease (MDRD) in patients with DKW/RBW ratio 2.5 g/kg and between 2.5 and 4.5 g/kg compared with those with DKW/RBW ratio >4.5 g/kg as well as in patients with DKW/RBW ratio <3 g/kg and between 3 and 4 g/kg compared with those with DKW/RBW ratio >4 g/kg; moreover a random coefficient model showed a different time evolution in creatinine clearance values in patients with DKW/RBW ≤ 3 g/kg when compared with patients with DKW/RBW ratio >4 g/kg. There were significant lower values of inulin clearance in patients with DKW/RBW ratio between 2.5 and 4.5 g/kg compared with those with DKW/RBW ratio >4.5 g/kg at 12 post‐transplant months and a significantly greater occurrence and earlier appearance of proteinuria in the recipients with DKW/RBW ratio <2.5 g/kg. DKW/RBW ratio did not influence DGF incidence and graft survival. Donor and recipient gender, number of acute rejection episodes and donor age also significantly influenced MDRD values.</p> </sec> <sec id="nep12277-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Measurements of graft weight as well as donor kidney and recipient body matching should be recommended as influencing renal function.</p> </sec> </abstract>