Preparation, characteristic and pharmacological study on inclusion complex of sulfobutylether‐β‐cyclodextrin with glaucocalyxin A. (12th February 2014)

• Record Type: Journal Article
• Authors: Ren, Lili; Jing, Jianghui; Chen, Guoguang; Miao, Yanfei; Wei, Ping
• Is Part Of: Journal of pharmacy and pharmacology. Volume 66:Number 7(2014:Jul.)
• Page Start: 927
• Page End: 934
• Publication Date: 2014-02-12
• Subjects: Pharmacy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/jphp.12219
• Languages: English
• ISSNs: 0022-3573

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jphp12219-sec-5001" sec-type="section"> <title>Objectives</title> <p>The objective of this study was to improve the water solubility and solubility of glaucocalyxin A (GLA) by producing its inclusion complex with sulfobutylether‐β‐cyclodextrin (SBE‐β‐CD).</p> </sec> <sec id="jphp12219-sec-5002" sec-type="section"> <title>Methods</title> <p>The formation of its 1 : 1 complex with SBE‐β‐CD in solution was confirmed by phase‐solution and spectral‐shift studies. The interaction of GLA and SBE‐β‐CD was examined by differential scanning calorimetry, powder X‐ray diffraction, Fourier transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy and ultraviolet‐visible spectroscopy to determine the formation of the GLA–SBE‐β‐CD inclusion complex.</p> </sec> <sec id="jphp12219-sec-5003" sec-type="section"> <title>Key findings</title> <p>The solubilities of GLA and its complexes were 2.38 × 10<sup>2</sup> and 1.82 × 10<sup>4</sup> μg/ml, respectively, and the values of the inclusion complexes were significantly improved by 76‐fold compared with the solubility of free GLA. Moreover, a higher area under the curve<sub>0–∞</sub> after inclusion technique was observed in the pharmacokinetics study.</p> </sec> <sec id="jphp12219-sec-5004" sec-type="section"> <title>Conclusions</title> <p>The aforementioned results indicate that GLA–SBE‐β‐CD could be useful with a better solubility and sustained function in drug delivery.</p> </sec> </abstract>