Clinical severity of rhinovirus/enterovirus compared to other respiratory viruses in children. Issue 4 (7th May 2014)

• Record Type: Journal Article
• Authors: Asner, Sandra A.; Petrich, Astrid; Hamid, Jemila S.; Mertz, Dominik; Richardson, Susan E.; Smieja, Marek
• Is Part Of: Influenza and other respiratory viruses. Volume 8:Issue 4(2014:Jul.)
• Page Start: 436
• Page End: 442
• Publication Date: 2014-05-07
• Subjects: Influenza -- Periodicals; Respiratory infections -- Periodicals; Virus diseases -- Periodicals; Influenza, Human -- Periodicals; Respiratory Tract Diseases -- Periodicals; Virus Diseases -- Periodicals; Grippe -- Périodiques; Appareil respiratoire -- Infections -- Périodiques; Maladies à virus -- Périodiques; 616.203
• DOI: 10.1111/irv.12255
• Languages: English
• ISSNs: 1750-2640

Abstract

<abstract abstract-type="main" id="irv12255-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="irv12255-sec-0001" sec-type="section"> <title>Background</title> <p>Human rhinovirus/enterovirus (HRV/ENT) infections are commonly identified in children with acute respiratory infections (ARIs), but data on their clinical severity remain limited.</p> </sec> <sec id="irv12255-sec-0002" sec-type="section"> <title>Objectives</title> <p>We compared the clinical severity of HRV/ENT to respiratory syncytial virus (RSV), influenza A/B (FLU), and other common respiratory viruses in children.</p> </sec> <sec id="irv12255-sec-0003" sec-type="section"> <title>Patients/Methods</title> <p>Retrospective study of children with ARIs and confirmed single positive viral infections on mid‐turbinate swabs by molecular assays. Outcome measures included hospital admission and, for inpatients, a composite endpoint consisting of intensive care admission, hospitalization >5 days, oxygen requirements or death.</p> </sec> <sec id="irv12255-sec-0004" sec-type="section"> <title>Results</title> <p>A total of 116 HRV/ENT, 102 RSV, 99 FLU, and 64 other common respiratory viruses were identified. Children with single HRV/ENT infections presented with significantly higher rates of underlying immunosuppressive conditions compared to those with RSV (37·9% versus 13·6%; <italic>P </italic>< 0·001), FLU (37·9% versus 22%; <italic>P </italic>= 0·018) or any other single viral infection (37·9% versus 22·5%; <italic>P </italic>= 0·024). In multivariable analysis adjusted for underlying conditions and age, children with HRV/ENT infections had increased odds of hospitalization compared to children with RSV infections (OR 2·6; 95% CI 1·4, 4·8; <italic>P </italic>< 0·003) or FLU infections (OR 3·0; 95% CI 1·6, 5·8; <0·001) and increased odds of severe clinical disease among inpatients (OR 3·0; 95% CI 1·6, 5·6; <italic>P </italic>= 0·001) when compared to those with FLU infections.</p> </sec> <sec id="irv12255-sec-0005" sec-type="section"> <title>Conclusions</title> <p>Children with HRV/ENT had a more severe clinical course than those with RSV and FLUA/B infections and often had significant comorbidities. These findings emphasize the importance of considering HRV/ENT infection in children presenting with severe acute respiratory tract infections.</p> </sec> </abstract>