Relationships between A(H1N1)pdm09 influenza infection and infections with other respiratory viruses. Issue 4 (4th April 2014)

• Record Type: Journal Article
• Authors: Meningher, Tal; Hindiyeh, Musa; Regev, Liora; Sherbany, Hilda; Mendelson, Ella; Mandelboim, Michal
• Is Part Of: Influenza and other respiratory viruses. Volume 8:Issue 4(2014:Jul.)
• Page Start: 422
• Page End: 430
• Publication Date: 2014-04-04
• Subjects: Influenza -- Periodicals; Respiratory infections -- Periodicals; Virus diseases -- Periodicals; Influenza, Human -- Periodicals; Respiratory Tract Diseases -- Periodicals; Virus Diseases -- Periodicals; Grippe -- Périodiques; Appareil respiratoire -- Infections -- Périodiques; Maladies à virus -- Périodiques; 616.203
• DOI: 10.1111/irv.12249
• Languages: English
• ISSNs: 1750-2640

Abstract

<abstract abstract-type="main" id="irv12249-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="irv12249-sec-0001" sec-type="section"> <title>Background</title> <p>A(H1N1)pdm09, a new influenza pandemic virus emerged in 2009. The A(H1N1)pdm09 infection had several unique characteristics which included rapid transmissibility and high morbidity in obese individuals, pregnant women and individuals suffering from chronic diseases.</p> </sec> <sec id="irv12249-sec-0002" sec-type="section"> <title>Objectives</title> <p>To study the relationships between A(H1N1)pdm09 influenza infection and infections with other respiratory viruses such as respiratory syncytial virus (RSV), human metapneumo virus (hMPV), adenovirus and seasonal influenza.</p> </sec> <sec id="irv12249-sec-0003" sec-type="section"> <title>Methods</title> <p>Samples (nasopharyngeal swabs or aspirates) collected between 2007 until 2012 from patients of various ages that were hospitalized due to respiratory virus infections were analyzed for the presence of various respiratory viruses, using qRT‐PCR.</p> </sec> <sec id="irv12249-sec-0004" sec-type="section"> <title>Results</title> <p>In 2009–2010, when the pandemic influenza A(H1N1)pdm09 first appeared, two major infection peaks were noted and individuals of various ages were infected. Following the decline of the A(H1N1)pdm09 virus infection, the percentages of patients infected with adenovirus and hMPV increased, while infection frequency with RSV B and with seasonal influenza virus decreased. Furthermore, RSV infections were delayed and very few percentages of patients were co‐infected with more than one virus. Interestingly, the A(H1N1)pdm09 virus lost its dominancy when it reappeared in the winter of 2010–2011, and at this time, only the incidence of RSV infections was affected by the A(H1N1)pdm09 virus.</p> </sec> <sec id="irv12249-sec-0005" sec-type="section"> <title>Conclusions</title> <p>The A(H1N1)pdm09 virus had distinct effects on other respiratory viruses when it first appeared versus later, when it evolved from being a pandemic to a seasonal virus.</p> </sec> </abstract>