Development of left ventricular hypertrophy in a novel porcine model of mitral regurgitation*. (June 2014)

• Record Type: Journal Article
• Authors: Ravn, Nathja; Zois, Nora E.; Moesgaard, Sophia G.; Honge, Jesper L.; Smerup, Morten H.; Hasenkam, J. Michael; Sloth, Erik; Cremer, Signe E.; Olsen, Lisbeth H.
• Is Part Of: Scandinavian cardiovascular journal. Volume 48:Number 3(2014:Jun.)
• Page Start: 189
• Page End: 195
• Publication Date: 2014-06
• Subjects: Cardiovascular system -- Diseases -- Periodicals; 617.41
• DOI: 10.3109/14017431.2014.895850
• Languages: English
• ISSNs: 1401-7431

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objectives.</italic> We aimed to develop a porcine model for chronic nonischemic mitral regurgitation (MR) to investigate left ventricular (LV) enlargement and eccentric hypertrophy. <italic>Design.</italic> Nonischemic MR was induced in 30 pigs by open-chest immobilization of the posterior mitral leaflet by transannular traction sutures that where applied in transmyocardial fashion. A sham operated control group (<italic>n</italic> = 13) was included. Echocardiographic LV size and heart weight assessed at euthanasia were used to evaluate the development of LV enlargement and eccentric hypertrophy after 8 weeks follow-up. <italic>Results.</italic> Eight pigs died and seven were excluded due to mediastinal infection (<italic>n</italic> = 2) or failure to produce MR (<italic>n</italic> = 5). Thus, 28 pigs were included and were divided into three groups: controls (<italic>n</italic> = 12), mild MR (mMR; <italic>n</italic> = 10), and moderate to severe MR (sMR; <italic>n</italic> = 6). The change in LV internal diameter in diastole (LVIDd) from baseline to follow-up was significantly higher in the sMR group compared to that of the control group (<italic>P</italic> = 0.0017). Furthermore, LV weight was significantly increased in the mMR (<italic>P</italic> = 0.047) and the sMR (<italic>P</italic> = 0.0087) groups compared to that of the control group. <italic>Conclusions.</italic> A new model for chronic moderate to severe nonischemic MR with development of LV enlargement and eccentric hypertrophy within 8 weeks has been established in pigs.</p> </abstract>