Antagonistic functions of LMNA isoforms in energy expenditure and lifespan. (17th March 2014) - Lopez‐Mejia, Isabel C
Synopsis The LMNA gene encodes functionally distinct isoforms that have opposite effects on energy metabolism and lifespan. Mice expressing lamin C only are obese and have an extended lifespan, whereas mice expressing progerin are lean and die early. Mice exclusively expressing the lamin C isoform exhibit decreased energy metabolism and mitochondrial activity. Exclusive lamin C expression in mice results in an increased lifespan and weight gain. Progerin‐expressing mice present a higher energy metabolism and are lipodystrophic. Key modulators of energy expenditure are inversely regulated in lamin C‐ and progerin‐expressing mice.