Somatic and axonal LIGHT signaling elicit degenerative and regenerative responses in motoneurons, respectively. (25th March 2014)

• Record Type: Journal Article
• Authors: Otsmane, Belkacem; Moumen, Anice; Aebischer, Julianne; Coque, Emmanuelle; Sar, Chamroeun; Sunyach, Claire; Salsac, Céline; Valmier, Jean; Salinas, Sara; Bowerman, Melissa; Raoul, Cédric
• Is Part Of: EMBO reports. Volume 15:Number 5(2014:May)
• Page Start: 540
• Page End: 547
• Publication Date: 2014-03-25
• Subjects: Molecular biology -- Periodicals; Molecular Biology -- Periodicals; Molecular biology; Periodicals; 572.8
• DOI: 10.1002/embr.201337948
• Languages: English
• ISSNs: 1469-221X

Abstract

<abstract abstract-type="synopsis" xml:lang="en" id="embr201337948-abs-0002"> <title>Synopsis</title> <p> <boxed-text content-type="graphic" id="embr201337948-blkfxd-0001" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pghjsq741t" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> <p>Activation of the LIGHT receptor LT‐βR in the somatic compartment of motoneurons elicits death, while activation in the axonal compartment stimulates axon outgrowth and branching. LIGHT also promotes functional recovery following peripheral nerve lesion.</p> <p> <list id="embr201337948-list-0001" list-type="bullet"> <list-item> <p>Somatic activation of LIGHT‐LT‐βR signaling triggers motoneuron death, while axonal activation increases motoneuron axon length and branching.</p> </list-item> <list-item> <p>LIGHT‐induced axon outgrowth and branching depend on ERK and caspase‐9 pathways</p> </list-item> <list-item> <p>Following peripheral nerve injury, LIGHT is required for reinnervation and functional recovery.</p> </list-item> </list> </p> </abstract>