Identification of Novel Predictive Markers for the Prognosis of Pancreatic Ductal Adenocarcinoma. (3rd July 2014)

• Record Type: Journal Article
• Authors: Jiang, Bing; Gu, Yonghong; Chen, Yuxiang
• Is Part Of: Cancer investigation. Volume 32:Number 6(2014)
• Page Start: 218
• Page End: 225
• Publication Date: 2014-07-03
• Subjects: Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2014.905586
• Languages: English
• ISSNs: 0735-7907

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>This study demonstrated that <italic>klotho</italic> gene expression was significantly lower whereas <italic>miR-504</italic> and phospho-IGF-1R levels were significantly higher in PDAC than in normal pancreatic tissues. <italic>miR-504</italic> level significantly correlated with <italic>klotho</italic> mRNA and promoter methylation level in PDACs. Loss of Klotho protein expression, <italic>klotho</italic> promoter hypermethylation, high <italic>miR-504</italic> levels, and high phospho-IGF-1R levels significantly correlated with poor survival, high clinical and pathological stages in PDAC patients. The demethylation reagent and <italic>miR-504</italic> inhibitor increased <italic>klotho</italic> gene expression, invasion, and migration in BxPC-3 and Panc-1 cells. Klotho is a tumor suppressor whose expression in PDAC correlated with progression and prognosis of PDAC.</bold> </p> </abstract>