Facile Preparation of Core–Shell Magnetic Metal–Organic Framework Nanospheres for the Selective Enrichment of Endogenous Peptides. Issue 24 (7th May 2014)

• Record Type: Journal Article
• Authors: Xiong , Zhichao; Ji , Yongsheng; Fang, Chunli; Zhang, Quanqing; Zhang, Lingyi; Ye, Mingliang; Zhang , Weibing; Zou, Hanfa
• Is Part Of: Chemistry. Volume 20:Issue 24(2014)
• Page Start: 7389
• Page End: 7395
• Publication Date: 2014-05-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201400389
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Facile preparation of core–shell magnetic metal–organic framework nanospheres by a layer‐by‐layer approach is presented. The nanospheres have high surface area (285.89 cm² g⁻¹), large pore volume (0.18 cm³ g⁻¹), two kinds of mesopores (2.50 and 4.72 nm), excellent magnetic responsivity (55.65 emu g⁻¹), structural stability, and good dispersibility. The combination of porosity, hydrophobicity, and uniform magnetism was exploited for effective enrichment of peptides with simultaneous exclusion of high molecular weight proteins. The nanospheres were successfully applied in the selective enrichment of endogenous peptides in human serum.</p> </abstract>