Whole‐Cell Biocatalysis in Deep‐Eutectic‐Solvents/Aqueous Mixtures. Issue 6 (24th March 2014)

• Record Type: Journal Article
• Authors: Maugeri, Zaira; Domínguez de María, Pablo
• Is Part Of: ChemCatChem. Volume 6:Issue 6(2014:Jun.)
• Page Start: 1535
• Page End: 1537
• Publication Date: 2014-03-24
• Subjects: Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201400077
• Languages: English
• ISSNs: 1867-3880

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Whole‐cell biocatalysis with the use of baker's yeast is demonstrated in different mixtures of water with deep eutectic solvents (DESs; choline chloride/glycerol, 1:2 mol/mol). Enantioselective ketone reduction is observed for long reaction times (&gt;200 h), which suggests that the whole cells remain stable in these neoteric solvents. By changing the proportion of the DES added, a complete inversion of enantioselectivity is observed, from approximately 95 % enantiomeric excess (<italic>ee</italic>) (<italic>S</italic>) in pure water to approximately 95 % <italic>ee</italic> (<italic>R</italic>) in the pure DES. Presumably, some (<italic>S</italic>)‐oxidoreductases present in baker's yeast are inhibited by DESs.</p> </abstract>