A retrospective study of positive pressure ventilation in 58 dogs: indications, prognostic factors and outcome. (3rd April 2014)

• Record Type: Journal Article
• Authors: Bruchim, Y.; Aroch, I.; Sisso, A.; Kushnir, Y.; Epstein, A.; Kelmer, E.; Segev, G.
• Is Part Of: Journal of small animal practice. Volume 55:Number 6(2014:Jun.)
• Page Start: 314
• Page End: 319
• Publication Date: 2014-04-03
• Subjects: Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; 636.089
• DOI: 10.1111/jsap.12211
• Languages: English
• ISSNs: 0022-4510

Abstract

<abstract abstract-type="main" id="jsap12211-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jsap12211-sec-0001" sec-type="section"> <title>OBJECTIVES</title> <p id="jsap12211-para-0001"> <bold>To assess the usefulness of clinical and clinicopathological parameters as prognostic markers of survival in dogs undergoing positive pressure ventilation</bold>.</p> </sec> <sec id="jsap12211-sec-0002" sec-type="section"> <title>METHODS</title> <p id="jsap12211-para-0002"> <bold>Retrospective study of case records of 58 client‐owned dogs undergoing positive pressure ventilation. Dogs were divided into two groups; inadequate oxygenation due to pulmonary parenchymal disease (Group 1) and inadequate ventilation (Group 2)</bold>.</p> </sec> <sec id="jsap12211-sec-0003" sec-type="section"> <title>RESULTS</title> <p id="jsap12211-para-0003"> <bold>Median duration of positive pressure ventilation was 30 (range 10 to 136) hours. Survival rate was 32% (19 dogs). Survivors were significantly younger (P<0·005) and had significantly higher (P<0·002) median PaO<sub>2</sub>/FiO<sub>2</sub> ratio at 4 to 12 hours postinitiation of positive pressure ventilation, and immediately before weaning (P<0·006) compared to non‐survivors. A receiver operator characteristics analysis of PaO<sub>2</sub>/FiO<sub>2</sub> immediately before weaning as predictor of survival had an area under the curve of 0·76 (95% confidence interval 0·54 to 0·97), with optimal cut‐off point of 252 mmHg, corresponding to a sensitivity and specificity of 0·80 and 0·79, respectively. The survival rates of dogs with PaO<sub>2</sub>/FiO<sub>2</sub> less than 200 mmHg at 4 to 12 hours postinitiation of positive pressure ventilation, or immediately before weaning were 15% (3/20 dogs) and 6% (1/16 dogs), respectively</bold>.</p> </sec> <sec id="jsap12211-sec-0004" sec-type="section"> <title>CLINICAL SIGNIFICANCE</title> <p id="jsap12211-para-0004"> <bold>The PaO<sub>2</sub>/FiO<sub>2</sub> ratio is an early prognostic indicator of successful weaning in dogs undergoing positive pressure ventilation</bold>.</p> </sec> </abstract>