Synthesis and Biological Activity of Quaternary Ammonium Salt‐Type Agents Containing Cholesterol and Terpenes. Issue 6 (24th March 2014)

• Record Type: Journal Article
• Authors: Novotná, Eva; Waisser, Karel; Kuneš, Jiří; Palát, Karel; Buchta, Vladimír; Stolaříková, Jiřina; Beckert, Rainer; Wsól, Vladimír
• Is Part Of: Archiv der Pharmazie. Volume 347:Issue 6(2014:Jun.)
• Page Start: 381
• Page End: 386
• Publication Date: 2014-03-24
• Subjects: Pharmaceutical chemistry -- Periodicals; Pharmacology -- Periodicals; 615.19
• DOI: 10.1002/ardp.201300407
• Languages: English
• ISSNs: 0365-6233

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ardp201300407-sec-0001" sec-type="section"> <p>New quaternary ammonium salt‐type compounds with lipophilic cholesterol and terpene moieties were synthesized. The compounds showed promising antibacterial and antimycobacterial activities. Those compounds containing the cholesterol moiety showed significant activity against <italic>Staphylococcus aureus</italic>, <italic>Staphylococcus epidermidis</italic>, and <italic>Enterococcus faecium</italic>. On the contrary, the antimycobacterial activity increased with the presence of the terpene unit in the molecule.</p> </sec> </abstract>