Response to pneumococcal vaccination in mannose‐binding lectin‐deficient adults with recurrent respiratory tract infections. (July 2014)

• Record Type: Journal Article
• Authors: van Kessel, D. A.; Hoffman, T. W.; van Velzen‐Blad, H.; Zanen, P.; Rijkers, G. T.; Grutters, J. C.
• Is Part Of: Clinical and experimental immunology. Volume 177:Number 1(2014:Jul.)
• Page Start: 272
• Page End: 279
• Publication Date: 2014-07
• Subjects: Immunopathology -- Periodicals; 616.079
• DOI: 10.1111/cei.12299
• Languages: English
• ISSNs: 0009-9104

Abstract

<abstract abstract-type="main"> <title>Summary</title> <p>Mannose‐binding lectin (MBL)‐deficiency is associated with an increased susceptibility to pneumococcal infections and other forms of disease. Pneumococcal vaccination is recommended in MBL‐deficient patients with recurrent respiratory tract infections (RRTI). The response to pneumococcal vaccination in MBL‐deficient individuals has not yet been studied in detail. An impaired response to pneumococcal polysaccharides in MBL‐deficient patients might explain the association between MBL deficiency and pneumococcal infections. This study investigates the antibody response to pneumococcal vaccination in MBL‐deficient adult patients with RRTI. Furthermore, we investigated whether there was a difference in clinical presentation between MBL‐deficient and ‐sufficient patients with RRTI. Eighteen MBL‐deficient and 63 MBL‐sufficient adult patients with RRTI were all vaccinated with the 23‐valent pneumococcal polysaccharide vaccine and antibodies to 14 pneumococcal serotypes were measured on a Luminex platform. There were no differences observed in the response to pneumococcal vaccination between MBL‐sufficient and ‐deficient patients. Forty‐three MBL‐sufficient patients could be classified as responders to pneumococcal vaccination and 20 as low responders, compared to 15 responders and three low responders in the MBL‐deficient patients. We found no clear difference in clinical, radiological, lung function and medication parameters between MBL‐sufficient and ‐deficient patients. In conclusion, our study suggests that MBL‐deficient adults with RRTI have a response to a pneumococcal capsular polysaccharide vaccine comparable with MBL‐sufficient patients. Moreover, we did not find a clear clinical role of MBL deficiency in adults with RRTI. As MBL deficiency is associated with an increased susceptibility to pneumococcal infections, pneumococcal vaccination might be protective in MBL‐deficient patients with RRTI.</p> </abstract>