Biobanks and personalized medicine. (27th March 2014)

• Record Type: Journal Article
• Authors: Olson, J.E.; Bielinski, S.J.; Ryu, E.; Winkler, E.M.; Takahashi, P.Y.; Pathak, J.; Cerhan, J.R.
• Is Part Of: Clinical genetics. Volume 86:Number 1(2014:Jul.)
• Page Start: 50
• Page End: 55
• Publication Date: 2014-03-27
• Subjects: Medical genetics -- Periodicals; 616.0420
• DOI: 10.1111/cge.12370
• Languages: English
• ISSNs: 0009-9163

Abstract

<abstract abstract-type="main" id="cge12370-abs-0001"> <title>Abstract</title> <p id="cge12370-para-0001">We provide a mini‐review of how biobanks can support clinical genetics in the era of personalized medicine. We discuss types of biobanks, including disease specific and general biobanks not focused on one disease. We present considerations in setting up a biobank, including consenting and governance, biospecimens, risk factor and related data, informatics, and linkage to electronic health records for phenotyping. We also discuss the uses of biobanks and ongoing considerations, including genotype‐driven recruitment, investigations of gene–environment associations, and the re‐use of data generated from studies. Finally, we present a brief discussion of some of the unresolved issues, such as return of research results and sustaining biobanks over time. In summary, carefully designed biobanks can provide critical research and infrastructure support for clinical genetics in the era of personalized medicine.</p> </abstract>