Disease‐specific mutations in mature lymphoid neoplasms: Recent advances. Issue 6 (12th May 2014)
- Record Type:
- Journal Article
- Title:
- Disease‐specific mutations in mature lymphoid neoplasms: Recent advances. Issue 6 (12th May 2014)
- Main Title:
- Disease‐specific mutations in mature lymphoid neoplasms: Recent advances
- Authors:
- Sakata‐Yanagimoto, Mamiko
Enami, Terukazu
Yokoyama, Yasuhisa
Chiba, Shigeru - Abstract:
- <abstract abstract-type="main" id="cas12408-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Mature lymphoid neoplasms (MLN) are clinically and pathologically more complex than precursor lymphoid neoplasms. Until recently, molecular characterization of MLN was mainly based on cytogenetics/fluorescence in situ hybridization, allele copy number, and mRNA expression, approaches that yielded scanty gene mutation information. Use of massive parallel sequencing technologies has changed this outcome, and now many gene mutations have been discovered. Some of these are considerably frequent in, and substantially specific to, distinct MLN subtypes, and occur at single or several hotspots. They include the V600E <italic>BRAF</italic> mutation in hairy cell leukemia, the L265P <italic>MYD88</italic> mutation in Waldenström macroglobulinemia, the G17V <italic>RHOA</italic> mutation in angioimmunoblastic T‐cell lymphoma and peripheral T‐cell lymphoma, not otherwise specified, and the Y640F//D661Y/V/H/I//N647I <italic>STAT3</italic> mutations in T‐cell large granular lymphocytic leukemia. Detecting these mutations is highly valuable in diagnosing MLN subtypes. Defining these mutations also sheds light on the molecular pathogenesis of MLN, furthering development of molecular targeting therapies. In this review, we focus on the disease‐specific gene mutations in MLN discovered by recent massive sequencing technologies.</p> </abstract>
- Is Part Of:
- Cancer science. Volume 105:Issue 6(2014:Jun.)
- Journal:
- Cancer science
- Issue:
- Volume 105:Issue 6(2014:Jun.)
- Issue Display:
- Volume 105, Issue 6 (2014)
- Year:
- 2014
- Volume:
- 105
- Issue:
- 6
- Issue Sort Value:
- 2014-0105-0006-0000
- Page Start:
- 623
- Page End:
- 629
- Publication Date:
- 2014-05-12
- Subjects:
- Cancer -- Periodicals
Neoplasms -- Periodicals
Research -- Periodicals
Electronic journals
616.994005 - Journal URLs:
- http://firstsearch.oclc.org ↗
http://firstsearch.oclc.org/journal=1347-9032;screen=info;ECOIP ↗
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1349-7006 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1111/cas.12408 ↗
- Languages:
- English
- ISSNs:
- 1347-9032
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3046.603000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 4036.xml