ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children. (15th March 2014)

• Record Type: Journal Article
• Authors: Kobayashi, Kenichiro; Mitsui, Kazumasa; Ichikawa, Hitoshi; Nakabayashi, Kazuhiko; Matsuoka, Masaki; Kojima, Yasuko; Takahashi, Hiroyuki; Iijima, Kazutoshi; Ootsubo, Kaori; Oboki, Keisuke; Okita, Hajime; Yasuda, Kazuki; Sakamoto, Hiromi; Hata, Kenichiro; Yoshida, Teruhiko; Matsumoto, Kenji; Kiyokawa, Nobutaka; Ohara, Akira
• Is Part Of: British journal of haematology. Volume 165:Number 6(2014:Jun.)
• Page Start: 836
• Page End: 841
• Publication Date: 2014-03-15
• Subjects: Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.12834
• Languages: English
• ISSNs: 0007-1048

Abstract

<abstract abstract-type="main" id="bjh12834-abs-0001"> <title>Summary</title> <p>We identified <italic>ATF7IP</italic> as a novel <italic>PDGFRB</italic> fusion partner in B‐progenitor acute lymphoblastic leukaemia (B‐ALL) and showed that B‐ALL with <italic>ATF7IP/PDGFRB</italic> translocation is included within the genomic lesions of a Philadelphia chromosome (Ph)‐like ALL subgroup. Comprehensive analyses of previous repositories of gene expression data sets disclosed that B‐ALL cases with high <italic>PDGFRB</italic> expression level in the context of the Ph‐like ALL gene are likely to have a <italic>PDGFRB</italic> translocation. Thus, it is possible that measurement of the <italic>PDGFRB</italic> expression level can be utilized as a screening test for the detection of the cryptic <italic>PDGFRB</italic> translocation, especially within the Ph‐like ALL subgroup.</p> </abstract>