Anti‐Markovnikov Hydroamination of Alkenes Catalyzed by a Two‐Component Organic Photoredox System: Direct Access to Phenethylamine Derivatives1. Issue 24 (24th April 2014)

• Record Type: Journal Article
• Authors: Nguyen, Tien M.; Manohar, Namita; Nicewicz, David A.
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 24(2014)
• Page Start: 6198
• Page End: 6201
• Publication Date: 2014-04-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201402443
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Disclosed herein is a general catalytic system for the intermolecular <italic>anti</italic>‐Markovnikov hydroamination of alkenes. By using an organocatalytic photoredox system, α‐ and β‐substituted styrenes as well as aliphatic alkenes undergo <italic>anti</italic>‐Markovnikov hydroamination. Heterocyclic amines were also successfully employed as nitrogen nucleophiles, thus providing a direct route to heterocyclic motifs common in medicinal agents.</p> </abstract>