Synthesis, Discovery, and Quantitation of Dihomo‐Isofurans: Biomarkers for In Vivo Adrenic Acid Peroxidation1. Issue 24 (18th May 2014)

• Record Type: Journal Article
• Authors: de La Torre, Aurélien; Lee, Yiu Yiu; Oger, Camille; Sangild, Per Torp; Durand, Thierry; Lee, Jetty Chung‐Yung; Galano, Jean‐Marie
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 24(2014)
• Page Start: 6249
• Page End: 6252
• Publication Date: 2014-05-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201402440
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The growing importance of lipidomics, and the interest of non‐enzymatic metabolites of polyunsaturated fatty acids (PUFAs) prompted us to initiate the synthesis of novel dihomo‐IsoF compounds. Such metabolites of adrenic acid, the main PUFA in white matter, were synthesized using a divergent approach based on an orthoester cyclization. LC‐MS/MS investigation on pig brains showed the potential of this novel biomarker for the first time, as a powerful new tool for brain lipid peroxidation assessment.</p> </abstract>