Back Cover: Sequential Intra‐Intercellular Nanoparticle Delivery System for Deep Tumor Penetration (Angew. Chem. Int. Ed. 24/2014). Issue 24 (23rd April 2014)

• Record Type: Journal Article
• Authors: Ju, Caoyun; Mo, Ran; Xue, Jingwei; Zhang, Lei; Zhao, Zekai; Xue, Lingjing; Ping, Qineng; Zhang, Can
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 24(2014)
• Page Start: 6278
• Page End: 6278
• Publication Date: 2014-04-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201401142
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A nanoparticle delivery system enables deep tumor penetration. As R. Mo, C. Zhang et al. show in their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 6253 ff., </ext-link> pH‐sensitive nanogels (small yellow spheres) accumulate at the tumor tissues (red cells). After internalization, the nanogels swell (large spheres) releasing the encapsulated chemotherapeutics (blue). The nanogel contracts (small yellow spheres), is liberated from the dead cells (grape‐like cells), infects neighboring cancer cells nearer the center of the tumor, and the process is repeated.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pghh51sd2x" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>