Synthesis, biological activities and SAR studies of novel 1‐Ethyl‐7‐methyl‐4‐oxo‐1, 4‐dihydro‐[1, 8]naphthyridine‐3‐carboxylic acid based diacyl and sulfonyl acyl hydrazines. Issue 7 (13th October 2013)

• Record Type: Journal Article
• Authors: Aggarwal, Nisha; Kumar, Rajesh; Srivastava, Chitra; Dureja, Prem; Khurana, J. M.
• Is Part Of: Pest management science. Volume 70:Issue 7(2014:Jul.)
• Page Start: 1071
• Page End: 1082
• Publication Date: 2013-10-13
• Subjects: Pests -- Control -- Periodicals; Pesticides -- Periodicals; 632.9
• DOI: 10.1002/ps.3650
• Languages: English
• ISSNs: 1526-498X

Abstract

<abstract abstract-type="main" id="ps3650-abs-0001"> <title>Abstract</title> <sec id="ps3650-sec-0001" sec-type="section"> <title>BACKGROUND</title> <p id="ps3650-para-0001"> <bold>Diacyl hydrazines have attracted significant interest in medicine, pesticide chemistry and material science. It is an important class of insect growth regulators. In this study, acyl hydrazine, the essential active group was incorporated in to nalidixic acid with the aim of combining the active groups to generate more potent agrochemical</bold>.</p> </sec> <sec id="ps3650-sec-0002" sec-type="section"> <title>RESULTS</title> <p id="ps3650-para-0002"> <bold>Various nalidixic acid based diacyl and sulphonyl acyl hydrazines derivatives were synthesized and characterized by spectral techniques. These compounds were screened for the antifungal activity against five pathogenic fungi, nitrification inhibitory activity and insect growth regulator (IGR) activity against <italic>Spodoptera litura</italic>. The fungicidal activity was screened against <italic>R. bataticola, S. rolfsii, R. solani, F. oxysporum</italic> and <italic>A. porri</italic>. Most of the compounds showed moderate to good antifungal activity against <italic>A. porri</italic> (ED<sub>50</sub> = 29.6‐495.9 µg/mL). All the compounds showed significant nitrification inhibitory activity at 5% level. IGR activity was examined by feeding method against <italic>S. litura</italic></bold>.</p> </sec> <sec id="ps3650-sec-0003" sec-type="section"> <title>CONCLUSION</title> <p id="ps3650-para-0003"> <bold>The study revealed that a few compounds possessed good activity against three different pests namely certain fungus, soil bacteria and insect, among which, compound 37 (R' = 4‐chlorophenyl) behaved the best. © 2013 Society of Chemical Industry</bold> </p> </sec> </abstract>