Transposition of the great arteries: factors influencing prenatal diagnosis. (3rd March 2014)

• Record Type: Journal Article
• Authors: Bertagna, F.; Rakza, T.; Vaksmann, G.; Ramdane‐Sebbane, N.; Devisme, L.; Storme, L.; Francart, C.; Vaast, P.; Houfflin‐Debarge, V.
• Is Part Of: Prenatal diagnosis. Volume 34:Number 6(2014:Jun.)
• Page Start: 534
• Page End: 537
• Publication Date: 2014-03-03
• Subjects: Prenatal diagnosis -- Periodicals; Fetus -- Diseases -- Diagnosis -- Periodicals; Electronic journals; 618.32075
• DOI: 10.1002/pd.4343
• Languages: English
• ISSNs: 0197-3851

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="pd4343-sec-0001" sec-type="section"> <title>Objective</title> <p>The objective of this study is to highlight the factors that may affect prenatal diagnosis of transposition of the great arteries (TGA) in order to improve it.</p> </sec> <sec id="pd4343-sec-0002" sec-type="section"> <title>Methods</title> <p>This is a retrospective study performed between 2004 and 2009 in the maternity units from North of France. We identified a total of 68 cases of TGA (isolated or associated with only VSD or coarctation of aorta), of which 32 (47.1%) had prenatal diagnosis (PND+) and 36 did not (PND−). Maternal characteristics and ultrasound factors were studied in relation to PND.</p> </sec> <sec id="pd4343-sec-0003" sec-type="section"> <title>Results</title> <p>Maternal weight and body mass index were significantly higher in the PND− group (70.4 kg and 26.5 kg/m<sup>2</sup> vs 63.6 kg and 23.6 kg/m<sup>2</sup>, respectively). Maternal obesity (body mass index >30) was significantly more frequent in the PND− group (27.8% vs 12.5%). More than a quarter of TGA (28.1%) were diagnosed during the third trimester.</p> </sec> <sec id="pd4343-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Obesity is the main cause of missed PND of TGA. Obese patients with suboptimal prenatal scans may benefit from reassessment of fetal cardiac anatomy and/or from referral for fetal echocardiography. © 2014 John Wiley & Sons, Ltd.</p> </sec> </abstract>